Nigeria stars Kelechi Iheanacho and Alex Iwobi will start for their respective Premier League clubs Manchester City and Arsenal.
However, the more experienced Nigeria international Ahmed Musa will again start from the bench for champions Leicester City against promoted Burnley.
With Sergio Aguero still suspended, rave-of-the moment Iheanacho will lead City’s attack at home against Bournemouth after scoring three important goals in 10 days.
The 19-year-old striker was the match winner for Nigeria in an AFCON qualifier against Tanzania, before he grabbed the match winner for City in the Manchester Derby.
He will then net his first Champions League goal against German Bundesliga side Borussia Monchengladbach at The Ettihad.
City have a perfect record of four wins in as many matches to lead the Premier League standings.
Iwobi, on the other hand, will start for The Gunners at Hull City after he also featured for the London in a 1-1 draw with PSGin a Champions League tie in midweek.
The 20-year-old Iwobi has returned from a three-week injury layoff.