Kenny Miller at Rangers training on FridayBBC coverageHow to follow:Listen on BBC Radio Scotland 810MW/DAB/online; text commentary on the BBC Sport website
Rangers play their first game since boss Pedro Caixinha's dismissal without the suspended Bruno Alves and injured Graham Dorrans and Fabio Cardoso.
But interim manager Graeme Murty has confirmed striker and club vice-captain Kenny Miller will be involved.
Miller was left out of the squad after a fall-out with Caixinha, while Ryan Jack is available after the club appealed against his recent red card.
Hearts are likely to be without midfielders Don Cowie and Arnaud Djoum.
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Rangers captain Lee Wallace is currently injured, while midfielder Dorrans limped off during the midweek 1-1 draw with Kilmarnock.
Jack was sent off towards the end of that match but the club's appeal will not be heard until after Saturday's game, leaving the midfielder free to play at Murrayfield.
Of Miller, Murty said: "Kenny will be involved - he's available for selection. Kenny is a fit player, he is ready to be involved and he's ready to go.
"There's not a lot of time but we need to make sure the players are content and happy, and that's my sole focus.
"The lads are a little bit unsure of themselves because there's uncertainty around after these things happen.
"But they are professional athletes and they know they are going to be judged on their performance.
"They know people in football are going to be looking for a reaction but they will be ready."
Source: bbc.com