Liverpool's big misses: Maguire, Keane, Sanchez, Bonucci, Howedes

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The crew answer your tweets on Jurgen Klopp's job security, the hype surrounding Dele Alli and Carlo Ancelotti's chances of managing Arsenal.

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Dejan Lovren has admitted he is taking up to five painkillers in order to play for Liverpool through injury. It's hardly an ideal situation, but Liverpool's options at centre-half are limited after they failed to land Virgil van Dijk in the summer.

ESPN FC looks at five deals for defenders in the transfer window that Jurgen Klopp may regret missing out on.

Harry Maguire to Leicester City

The £17 million the Foxes paid is becoming an extremely shrewd piece of businesses in this uncertain market. Maguire has slotted seamlessly into his new club and earned international recognition as a result, receiving his first England call-up in August. "I don't see why he couldn't be a future England captain," Leicester boss Craig Shakespeare said. The 24-year-old is an all-round centre-back -- comfortable with the ball at his feet and strong in duels -- and has played every minute of Leicester's Premier League campaign so far this season. The fact he was part of a Hull City back four that were relegated to the Championship didn't put Liverpool off from signing Andrew Robertson.

Michael Keane to Everton

Everton spent £30m on Keane, with sources telling ESPN FC that Liverpool and Manchester United were interested in the player at one stage. Whether Keane would have been an upgrade on Joel Matip and Lovren remains to be seen, given the indifferent start to his Everton career.

However, with Ragnar Klavan Klopp's third choice at centre-half, Keane, capped twice by England, would ensure the drop-off is less significant when the usual starters are unavailable.

Davinson Sanchez to Tottenham

Despite having Jan Vertonghen and Toby Alderweireld -- arguably the best centre-back partnership in the Premier League -- Spurs chairman Daniel Levy was willing to break the club's transfer record to land £42m Sanchez from Ajax.

Mauricio Pochettino has high hopes for Sanchez, believing the 21-year-old Colombian can develop into "one of the best centre-backs in the world" and he showed that by impressing in the Champions League win over Borussia Dortmund.

Klopp recently confirmed Sanchez was one of the defenders Liverpool had scouted, along with Napoli's Kalidou Koulibaly, but didn't go on to pursue a deal. When asked whether Sanchez or Koulibaly would have been candidates to bolster his backline, Klopp replied: "No. We watched all of them 500 million times."

Davinson Sanchez to Tottenham moved to Tottenham despite interest from Liverpool.

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Leonardo Bonucci to AC Milan

Bonucci, still considered to be one of the best centre-backs in the world, left Juventus in a shock switch last summer. With the chance to land an elite centre-back, AC Milan general manager Marco Fassone revealed it took just half an hour to complete a deal.

Bonucci is the joint-highest best paid player in the Italy, reportedly earning €7.5m-a-year after taxes, but AC Milan were more than willing to pay him that and then hand him the captaincy.

With a dearth of world-class options available, the opportunity to sign a player of Bonucci's calibre comes around once in a blue moon. Liverpool must be disappointed they were not part of the conversation for a deal with the Italy international.

Benedikt Howedes to Juventus

To strengthen after Bonucci's departure, Juventus moved quickly to sign Howedes from Schalke. A World Cup winner and blessed with five seasons of Champions League experience, the 29-year-old would have been an adequate option at centre-back, even if he fell down the pecking order and was stripped him of the captain's armband at Schalke last season.

The German joined the Serie A club on a one-year loan for a reported fee of €3.5m with a view to a permanent transfer, which would be worth €13.5m and triggered if he plays at least 25 times this season.

Glenn is ESPN FC's Liverpool correspondent. You can follow him on Twitter: @GlennPrice94.

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Source: espn.co.uk